| First Author | Takashita E | Year | 1994 |
| Journal | J Cell Physiol | Volume | 161 |
| Issue | 2 | Pages | 367-73 |
| PubMed ID | 7962121 | Mgi Jnum | J:23711 |
| Mgi Id | MGI:71402 | Doi | 10.1002/jcp.1041610222 |
| Citation | Takashita E, et al. (1994) Induction of bcl-2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA-1 cells. J Cell Physiol 161(2):367-73 |
| abstractText | When interleukin-3 (IL-3) dependent DA-1 cells were cultured on hemopoietic supportive stromal cells (MS-5), DA-1 cells survived and proliferated in the absence of detectable IL-3. Although IL-3 was not produced by the MS-5 cells, their production of granulocyte-macrophage colony-stimulating factor (GM-CSF) was increased when they were co-cultured with DA-1 cells. This suggests that DA-1 cells transmit signals to stromal cells that enhance growth factor(s) production. Expression of bcl-2 by DA-1 cells was induced when they were co-cultured with MS-5 cells, suggesting that DA-1 cells express bcl-2 strongly in response to a signal produced by MS-5 cells. These data indicate the existence of a two-way interaction between DA-1 cells and hemopoietic supportive stromal cells. |
