| First Author | Lee JC | Year | 1994 |
| Journal | Nature | Volume | 372 |
| Issue | 6508 | Pages | 739-46 |
| PubMed ID | 7997261 | Mgi Jnum | J:22034 |
| Mgi Id | MGI:69928 | Doi | 10.1038/372739a0 |
| Citation | Lee JC, et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372(6508):739-46 |
| abstractText | Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production. |
