| First Author | Löster J | Year | 1994 |
| Journal | Genomics | Volume | 23 |
| Issue | 1 | Pages | 240-2 |
| PubMed ID | 7829079 | Mgi Jnum | J:20146 |
| Mgi Id | MGI:68260 | Doi | 10.1006/geno.1994.1484 |
| Citation | Loster J, et al. (1994) Close linkage of the dominant cataract mutations (Cat-2) with Idh-1 and cryge on mouse chromosome 1. Genomics 23(1):240-2 |
| abstractText | The murine dominant gene Cat-2 was located on chromosome 1 between the loci of fuzzy and leaden. Subsequent linkage analysis revealed one recombinant between Cat-2t and isocitrate dehydrogenase-1, and one between Cat-2t and gamma E-crystallin among 338 offspring in three-point backcrosses. The resulting genetic distance between the loci is 0.3 +/- 0.3 cM. The very close linkage between the Cat-2 and the gamma-crystallin gene cluster together with the finding of reduced gamma-crystallin transcripts in mutant lenses suggest strongly that the gamma-crystallin genes may be candidate genes for the Cat-2 mutations. |
