| First Author | Walter CA | Year | 1994 |
| Journal | Somat Cell Mol Genet | Volume | 20 |
| Issue | 6 | Pages | 451-61 |
| PubMed ID | 7892645 | Mgi Jnum | J:23954 |
| Mgi Id | MGI:71742 | Doi | 10.1007/BF02255837 |
| Citation | Walter CA, et al. (1994) Testis and somatic Xrcc-1 DNA repair gene expression. Somat Cell Mol Genet 20(6):451-61 |
| abstractText | The human XRCC1 gene has been shown to be involved in DNA strand-break repair using the Chinese hamster ovary cell mutant EM9. The purpose of this study was to characterize the expression of Xrcc-1 to determine if there is tissue-specific expression and to provide a baseline of information for future studies that may involve altering Xrcc-1 expression in mice. Normal young adult male testis and enriched populations of pachytene spermatocytes and round spermatids displayed significantly higher levels of Xrcc-1 expression than other mouse tissues, although Xrcc-1 transcripts were found in low abundance in all tested tissues. Cultured mouse cell lines displayed levels of expression similar to male germ cells, which is a striking contrast to the levels of expression obtained in somatic tissues from the mouse. The relatively high levels of expression identified in male germ cells indicate Xrcc-1 may have an important role in male germ cell physiology. |
