| First Author | Krzanowska H | Year | 1994 |
| Journal | Mol Reprod Dev | Volume | 39 |
| Issue | 4 | Pages | 347-54 |
| PubMed ID | 7893483 | Mgi Jnum | J:21822 |
| Mgi Id | MGI:69728 | Doi | 10.1002/mrd.1080390402 |
| Citation | Krzanowska H, et al. (1994) Frequency of X-Y chromosome dissociation in mouse spermatocytes from interstrain crosses, recombinant inbred strains, and chimeras: possible involvement of paternal genome imprinting. Mol Reprod Dev 39(4):347-54 |
| abstractText | The frequency of dissociation of the X-Y chromosome bivalent in diakinesis-metaphase I spermatocytes differs significantly between two inbred mouse strains, CBA (29%) and KE (7%), that were used to obtain reciprocal F1 hybrids, and to develop recombinant inbred (RI) strains. The level of X-Y dissociation was significantly higher in (KExCBA)F1 hybrids sired by the CBA males (24%) than in reciprocal F1 hybrids (12%), revealing the inheritance after the father. Among 14 RI strains, nine were concordant with KE, one with CBA, and four had intermediate phenotype, significantly different from both progenitor strains. This shows that at least two genes are involved, and their possible linkage with agouti and Trf loci is suggested. The linkage with agouti was confirmed by testing additional 10 CBXE incipient RI strains. There was no significant difference in the level of X-Y dissociation between EXCB RI strains derived from the original cross sired by the CBA males and CBXE RI strains derived from the reciprocal cross. The involvement of the Y chromosome-linked factors was unlikely because it was found earlier (Krzanowska, 1989: Gamete Res 23:357-365) that two congenic strains, KE and KE.CBA, differing with respect to the source of the Y chromosome, had the same level of X-Y dissociation. Thus, the difference obtained between reciprocal F1 hybrids is interpreted in terms of paternal genome imprinting imposed by CBA males and propagated only in the presence of some alleles derived from this strain.(ABSTRACT TRUNCATED AT 250 WORDS) |
