| First Author | Lee A | Year | 1994 |
| Journal | Eur J Gastroenterol Hepatol | Volume | 6 Suppl 1 |
| Pages | S67-71 | PubMed ID | 7735939 |
| Mgi Jnum | J:26966 | Mgi Id | MGI:74387 |
| Citation | Lee A (1994) The use of a mouse model in the study of Helicobacter sp.-associated gastric cancer. Eur J Gastroenterol Hepatol 6 Suppl 1:S67-71 |
| abstractText | HYPOTHESIS: Long-term infection with Helicobacter pylori and the associated gastritis is now thought to cause a predisposition to gastric cancer through cellular changes resulting from inflammatory damage or because of direct effects of the bacterium. MICE AS MODELS FOR H. PYLORI-ASSOCIATED GASTRIC CANCER: Long-term infection of conventional Swiss mice with either H. felis or H. heilmannii results in atrophic gastritis. Infection of specific pathogen-free Balb/c mice results in the development of lesions similar to H. pylori-associated low-grade B-cell gastric lymphomas. CONCLUSION: H. pylori-infected mice appear to be excellent models for the study of tumours induced by this bacterium. |
