| First Author | Kalman B | Year | 1995 |
| Journal | J Neuroimmunol | Volume | 59 |
| Issue | 1-2 | Pages | 195-9 |
| PubMed ID | 7541056 | Mgi Jnum | J:27346 |
| Mgi Id | MGI:74757 | Doi | 10.1016/0165-5728(95)00042-z |
| Citation | Kalman B, et al. (1995) Junctional region of the myelin basic protein-specific T cell receptor beta chain in mice. J Neuroimmunol 59(1-2):195-9 |
| abstractText | Evidence for the existence of both conserved and diverse amino acid sequences in the junctional regions of the myelin basic protein (MBP)-specific T cell receptors (TCR) in mice is presented. The junctional region of the Nac1-11 MBP peptide-specific, H-2u-restricted TCR beta-chains is characterized by the utilization of similar amino acid sequences. In contrast, diverse junctional sequences within the TCR beta-chains of the p89-101 MBP peptide and H-2s-restricted T cell clones are reported. These findings demonstrate that a limited heterogeneity of the MBP-specific T cell clones does exist. However, it may not be universal even in inbred mouse strains. |
