| First Author | Kao KR | Year | 1995 |
| Journal | Mech Dev | Volume | 50 |
| Issue | 1 | Pages | 57-69 |
| PubMed ID | 7605752 | Mgi Jnum | J:25143 |
| Mgi Id | MGI:72871 | Doi | 10.1016/0925-4773(94)00325-h |
| Citation | Kao KR, et al. (1995) Expression of Xkl-1, a Xenopus gene related to mammalian c-kit, in dorsal embryonic tissue. Mech Dev 50(1):57-69 |
| abstractText | In mice, the Kit receptor tyrosine kinase and its ligand, Steel factor, are required for melanogenesis, hematopoesis and gametogenesis We have identified a Xenopus gene, Xkl-1 (Xenopus Kit-like-1) whose predicted protein has striking sequence identity in the catalytic domain and kinase insert to that of c-kit. Xkl-1 is expressed only in dorsal tissues such as the nervous system, notochord and somites of neurulae. Ultraviolet irradiated embryos and animal caps treated with basic FGF unexpectedly express Xkl-1, since they are considered to develop only ventral type tissues. These observations raise the hypothesis that Xkl-1 is involved in Xenopus dorsal development and that dorsal tissues inhibit the expression of Xkl-1 in ventral structures. |
