| First Author | Whitmarsh AJ | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5222 | Pages | 403-7 |
| PubMed ID | 7618106 | Mgi Jnum | J:40253 |
| Mgi Id | MGI:87598 | Doi | 10.1126/science.7618106 |
| Citation | Whitmarsh AJ, et al. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269(5222):403-7 |
| abstractText | The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli. |
