| First Author | Ellis MJ | Year | 1995 |
| Journal | J Mol Endocrinol | Volume | 14 |
| Issue | 2 | Pages | 191-8 |
| PubMed ID | 7619208 | Mgi Jnum | J:29318 |
| Mgi Id | MGI:76847 | Doi | 10.1677/jme.0.0140191 |
| Citation | Ellis MJ, et al. (1995) A novel cyclic AMP response element-binding protein-1 (CREB-1) splice product may down-regulate CREB-1 activity. J Mol Endocrinol 14(2):191-8 |
| abstractText | In this report we identify novel spliced forms of cyclic AMP (cAMP) response element-binding protein-1 (CREB-1) mRNA. These forms contained an additional 17 nucleotide insert, which we refer to as the beta exon, located between exons 4 and 7 of the delta, and 5 and 7 of the alpha forms of CREB-1 transcript (nomenclature of Ruppert et al. 1992; EMBO Journal 11, 1503-1512). The inclusion of the beta exon led to the generation of mRNAs in which the frame of CREB-1 sequences 3' to the exon was shifted such that the encoded proteins terminate after the transactivation domain, but before the target serine for cAMP-dependent protein kinase. The beta exon-containing CREB-1 mRNAs were more abundant in tissues that respond poorly to cAMP, suggesting that the generation of beta CREB-1 mRNAs may contribute to the down-regulation of CREB-1 activity and cAMP responsiveness. |
