| First Author | Schmitt J | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 213 |
| Issue | 1 | Pages | 211-7 |
| PubMed ID | 7639738 | Mgi Jnum | J:27982 |
| Mgi Id | MGI:75616 | Doi | 10.1006/bbrc.1995.2118 |
| Citation | Schmitt J, et al. (1995) Genomic organization of a mouse type I activin receptor. Biochem Biophys Res Commun 213(1):211-7 |
| abstractText | We have characterized the genomic organization of a mouse type I activin receptor. Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library. The mouse ActRIA gene is encoded by 10 exons and spans approximately 40 kb. The size of the introns was determined and the intron/exon boundaries were sequenced. Primer extension analysis of the 5' non-translated region using RNA from different organs or tissues revealed a strong transcription start site 68 nucleotides upstream of the ATG. Knowledge of the structure of the ActRIA gene is essential for the production of ActRIA deficient mice by homologous recombination. |
