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Publication : Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2).

First Author  Ikegawa S Year  1995
Journal  Cytogenet Cell Genet Volume  71
Issue  2 Pages  182-6
PubMed ID  7656593 Mgi Jnum  J:46010
Mgi Id  MGI:1196875 Doi  10.1159/000134103
Citation  Ikegawa S, et al. (1995) Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). Cytogenet Cell Genet 71(2):182-6
abstractText  Colligin, a collagen-binding glycoprotein localized to endoplasmic reticulum, belongs to the serpin superfamily. Colligin has been identified and cloned in a number of species including mouse, rat, chicken, and human. We have isolated and characterized a full-length human cDNA clone that encodes a 418-amino-acid peptide that is highly homologous (97% identity) to the previously reported human colligin gene, and have named this new member of the colligin family human colligin-2. The expression of the colligin-2 gene (CBP2) is ubiquitous among all normal human tissues except for brain and peripheral leukocytes. We have mapped this novel gene to chromosomes 11q13.5 by fluorescent in situ hybridization (FISH) using a cosmid clone containing the entire coding sequence and the 3' non-coding sequence.
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