| First Author | Faulds G | Year | 1995 |
| Journal | Br J Rheumatol | Volume | 34 |
| Issue | 7 | Pages | 610-5 |
| PubMed ID | 7670777 | Mgi Jnum | J:29623 |
| Mgi Id | MGI:77149 | Doi | 10.1093/rheumatology/34.7.610 |
| Citation | Faulds G, et al. (1995) Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-lpr/lpr mice. Br J Rheumatol 34(7):610-5 |
| abstractText | Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease. |
