| First Author | Blair HJ | Year | 1995 |
| Journal | Genomics | Volume | 28 |
| Issue | 2 | Pages | 305-10 |
| PubMed ID | 8530041 | Mgi Jnum | J:26635 |
| Mgi Id | MGI:75656 | Doi | 10.1006/geno.1995.1146 |
| Citation | Blair HJ, et al. (1995) High-resolution comparative mapping of the proximal region of the mouse X chromosome. Genomics 28(2):305-10 |
| abstractText | The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. In the mouse, the order of loci and evolutionary breakpoints (EB) has been established as centromere-(DXWas70, DXHXF34h)-EB-Clcn5-(Syp, DXMit55, DXMit26)-Tfe3-Gata1-EB-Xk-Cybb-telomere. In the proximal region of the human X chromosome short arm, the position of evolutionary breakpoints with respect to key loci has been established as DMD-EB-XK-PFC-EB-GATA1-C1CN5-EB-DXS1272E-ALAS2-E B-DXF34-centromere. These data have enabled us to construct a high-resolution genetic map for the approximately 3-cM interval between DXWas70 and Cybb on the mouse X chromosome, which encompasses 10 loci. This detailed map demonstrates the power of high-resolution genetic mapping in the mouse as a means of determining locus order in a small chromosomal region and of providing an accurate framework for the construction of physical maps. |
