| First Author | Balomenos D | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 7 | Pages | 3308-12 |
| PubMed ID | 7561023 | Mgi Jnum | J:28781 |
| Mgi Id | MGI:76320 | Doi | 10.4049/jimmunol.155.7.3308 |
| Citation | Balomenos D, et al. (1995) Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells. J Immunol 155(7):3308-12 |
| abstractText | Recent studies have documented incomplete TCR V alpha-chain allelic exclusion and dual V alpha-bearing T cells. Herein, we show that V beta allelic exclusion is also incomplete, since a significant proportion of peripheral T cells express dual V beta in both TCR transgenic and normal mice. Studies in TCR transgenic mice indicated that although a small proportion of T cells escaped allelic exclusion in the thymus, dual V beta-expressing cells expanded dramatically in the periphery with age, and such expanded cells had an activated phenotype. Although not as pronounced, age-related increases in dual V beta-bearing cells were also observed in normal mice. These findings may have important implications for TCR selection and specificity, age-related repertoire changes, and autoimmune disease pathogenesis. |
