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Publication : The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.

First Author  Giguère V Year  1995
Journal  Genomics Volume  28
Issue  3 Pages  596-8
PubMed ID  7490103 Mgi Jnum  J:28416
Mgi Id  MGI:76034 Doi  10.1006/geno.1995.1197
Citation  Giguere V, et al. (1995) The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. Genomics 28(3):596-8
abstractText  ROR alpha is a novel member of the steroid/thyroid/retinoid receptor superfamily with unique DNA-binding properties. We have mapped the RORA gene by fluorescence in situ hybridization to human chromosome 15q21-q22. To map the mouse Rora gene, a partial mouse cDNA clone was isolated from brain. Using interspecific backcross analysis, we have mapped the Rora gene to mouse chromosome 9. This places the human RORA gene in the proximity of the PML gene, which is involved in a reciprocal chromosomal translocation t(15:17) with the RARA gene in patients with acute promyelocytic leukemia.
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