First Author | Viville S | Year | 1995 |
Journal | Bioessays | Volume | 17 |
Issue | 10 | Pages | 835-8 |
PubMed ID | 7487965 | Mgi Jnum | J:29821 |
Mgi Id | MGI:77337 | Doi | 10.1002/bies.950171004 |
Citation | Viville S, et al. (1995) Towards unravelling the Igf2/H19 imprinted domain. Bioessays 17(10):835-8 |
abstractText | Genomic imprinting is an epigenetic marking process that confers parent-of-origin-dependent expression on certain genes. These imprinted genes are sometimes found in clusters, suggesting a possible involvement of higher order regulatory elements controlling expression and imprinting of genes organised in such clusters. In the distal chromosome 7 there are at least four imprinted genes: Mash2, Ins2, Igf2 and H19. Recent evidence suggests that imprinting and expression of at least Igf2 and H19 may be mechanistically linked. |