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Publication : Genetic mapping and expression analysis of the murine DNA ligase I gene.

First Author  Gariboldi M Year  1995
Journal  Mol Carcinog Volume  14
Issue  2 Pages  71-4
PubMed ID  7576101 Mgi Jnum  J:30180
Mgi Id  MGI:77694 Doi  10.1002/mc.2940140202
Citation  Gariboldi M, et al. (1995) Genetic mapping and expression analysis of the murine DNA ligase I gene. Mol Carcinog 14(2):71-4
abstractText  We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.
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