| First Author | Reya T | Year | 1996 |
| Journal | Blood | Volume | 87 |
| Issue | 1 | Pages | 190-201 |
| PubMed ID | 8547641 | Mgi Jnum | J:31368 |
| Mgi Id | MGI:78870 | Doi | 10.1182/blood.v87.1.190.bloodjournal871190 |
| Citation | Reya T, et al. (1996) Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development. Blood 87(1):190-201 |
| abstractText | To determine whether signaling via CD122 (interleukin-2 [IL-2]/IL-15 receptor beta-chain) plays a role in regulating the expansion and differentiation of lymphocyte precursors, we have characterized its expression and evaluated its ability to influence the activity of developing lymphoid cells. A significant fraction of Sca1+Lin- hematopoietic stem cells in day 12 fetal liver were found to be CD122+. CD122-mRNA+ and IL-2-mRNA+ cells were also localized in embryo sections within pharyngeal blood vessels adjacent to and surrounding the thymic analgen. This distribution is consistent with the migration of CD122+ progenitor cells from the liver to the developing thymus where a majority of Sca1+ intrathymic T-cell progenitors were CD122+. Analysis of CD122 expression in the day 12 fetal liver revealed that the majority of B220+ cells were CD122+. Furthermore, CD122 expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. Consistent with a role for the IL-2/IL-2R pathway in lymphocyte development is the progressive loss of B cells seen in IL-2-deficient mice. Together, these observations suggest that CD122 plays a role in regulating normal lymphocyte development in vivo. |
