| First Author | Sanvito F | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 217 |
| Issue | 3 | Pages | 1279-86 |
| PubMed ID | 8554587 | Mgi Jnum | J:30417 |
| Mgi Id | MGI:77928 | Doi | 10.1006/bbrc.1995.2906 |
| Citation | Sanvito F, et al. (1995) TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. Biochem Biophys Res Commun 217(3):1279-86 |
| abstractText | We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganization of the islets of Langerhans was also observed; however, the number of beta cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells. |
