| First Author | Harwood G | Year | 1995 |
| Journal | FEBS Lett | Volume | 377 |
| Issue | 1 | Pages | 73-6 |
| PubMed ID | 8543023 | Mgi Jnum | J:30236 |
| Mgi Id | MGI:77750 | Doi | 10.1016/0014-5793(95)01308-3 |
| Citation | Harwood G, et al. (1995) Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors. FEBS Lett 377(1):73-6 |
| abstractText | The genes encoding the rabbit 5HT1D alpha and 5HT1D beta receptors have been cloned. The deduced amino acid sequence of these receptors shows 91-92% amino acid sequence identity with their human homologues, and similar high sequence identity with homologues from other species. The receptors were transiently expressed in COS-7 cells and exhibit a pharmacological profile closely resembling their human homologues, including a higher affinity of ketanserin for the 5-HT1D alpha subtype. However, sumatriptan had a lower affinity for both the rabbit receptors compared to their human counterparts. This may be accounted for by differences between the primary amino acid sequences of these species homologues. |
