| First Author | Kessler E | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5247 | Pages | 360-2 |
| PubMed ID | 8553073 | Mgi Jnum | J:30854 |
| Mgi Id | MGI:78424 | Doi | 10.1126/science.271.5247.360 |
| Citation | Kessler E, et al. (1996) Bone morphogenetic protein-1: the type I procollagen C-proteinase. Science 271(5247):360-2 |
| abstractText | Bone morphogenetic proteins (BMPs) are bone-derived factors capable of inducing ectopic bone formation. Unlike other BMPs, BMP-1 is not like transforming growth factor-beta (TGF-beta), but it is the prototype of a family of putative proteases implicated in pattern formation during development in diverse organisms. Although some members of this group, such as Drosophila tolloid (TLD), are postulated to activate TGF-beta-like proteins, actual substrates are unknown. Procollagen C-proteinase (PCP) cleaves the COOH-propeptides of procollagens I, II, and III to yield the major fibrous components of vertebrate extracellular matrix. Here it is shown that BMP-1 and PCP are identical. This demonstration of enzymatic activity for a BMP-1/TLD-like protein links an enzyme involved in matrix deposition to genes involved in pattern formation. |
