| First Author | Gershengorn MC | Year | 1996 |
| Journal | Physiol Rev | Volume | 76 |
| Issue | 1 | Pages | 175-91 |
| PubMed ID | 8592728 | Mgi Jnum | J:31150 |
| Mgi Id | MGI:78634 | Doi | 10.1152/physrev.1996.76.1.175 |
| Citation | Gershengorn MC, et al. (1996) Molecular and cellular biology of thyrotropin-releasing hormone receptors. Physiol Rev 76(1):175-91 |
| abstractText | Thyrotropin-releasing hormone (TRH) receptor (TRH-R) complementary DNAs have been cloned from several species. The deduced amino acid sequences are compatible with TRH-R being a seven-transmembrane-spanning G protein-coupled receptor. These complementary DNAs and reagents derived from them have permitted detailed study of TRH-R biology at the molecular and cellular levels. Studies that have been performed since 1990 are reviewed in this article under the following headings: TRH-R gene, tissue distribution of TRH-R, primary structure of TRH-Rs, three-dimensional structure of the TRH-R binding pocket, TRH-R and G proteins, TRH-R activation, TRH desensitization, TRH-R endocytosis, and regulation of TRH-R number. It is evident that many new insights into the structure, function, and regulation of TRH-Rs have been gained in the last several years but that our understanding of these processes is incomplete. We look forward to even greater progress in the future. |
