| First Author | Kleeberger SR | Year | 1995 |
| Journal | Toxicol Lett | Volume | 82-83 |
| Pages | 295-300 | PubMed ID | 8597068 |
| Mgi Jnum | J:31815 | Mgi Id | MGI:79309 |
| Doi | 10.1016/0378-4274(95)03564-8 | Citation | Kleeberger SR (1995) Genetic susceptibility to ozone exposure. Toxicol Lett 82-3:295-300 |
| abstractText | Because of the impact that oxidizing air pollutants such as ozone (O-3) may have on public health, identification of factors that influence susceptibility to exposure remains a critical issue. The role of genetic background as a susceptibility factor is becoming increasingly clear. In this paper, evidence is reviewed which suggests that susceptibility to O-3 is a heritable trait in humans. Experimental studies are also described that characterize the mode of inheritance of O-3-induced lung injury in inbred strains of mice. It is suggested that future investigations should strive to identify phenotypic markers of susceptibility as a means to identify individuals who are genetically at risk for the development of oxidant-induced lung injury. |
