| First Author | Palacios J | Year | 1995 |
| Journal | Int J Dev Biol | Volume | 39 |
| Issue | 4 | Pages | 663-6 |
| PubMed ID | 8619966 | Mgi Jnum | J:30280 |
| Mgi Id | MGI:77793 | Citation | Palacios J, et al. (1995) Differential spatiotemporal expression of E- and P-cadherin during mouse tooth development. Int J Dev Biol 39(4):663-6 |
| abstractText | Changes in E- and P-cadherin (E- and P-CD) expression during embryonic mouse first molar development were analyzed by immunohistochemistry. During the induction and morphogenesis stages (bud, cap and early bell stages), E-CD was expressed in the cells of the invaginating epithelial tooth bud and in the cells of the outer enamel epithelium, stellate reticulum and stratum intermedium, suggesting a role for this molecule in the maintenance of enamel organ architecture. On the other hand, P-CD was strongly expressed in the inner enamel epithelium suggesting its participation in the processes of mesenchymal induction. during the cytodifferentiation stage (late bell stage), E-CD was expressed in polarizing preameloblasts, but cadherin expression was restricted to the basal and apical poles of differentiated secretory ameloblasts, where the zonula adherens type of cell-cell junctions is located. The present study demonstrates for the first time the spatiotemporal expression of cadherins during tooth development and suggests differential and specific roles for E-CD and P-CD during the morphogenesis and cytodifferentiation processes of this organ. |
