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Publication : Localization of the mouse lissencephaly-1 gene to mouse chromosome 11B3, in close proximity to D11Mit65.

First Author  Péterfy M Year  1995
Journal  Somat Cell Mol Genet Volume  21
Issue  5 Pages  345-9
PubMed ID  8619131 Mgi Jnum  J:31743
Mgi Id  MGI:79674 Doi  10.1007/BF02257469
Citation  Peterfy M, et al. (1995) Localization of the mouse lissencephaly-1 gene to mouse chromosome 11B3, in close proximity to D11Mit65. Somat Cell Mol Genet 21(5):345-9
abstractText  Lissencephaly is a human brain malformation manifested by a smooth cerebral surface and severe mental retardation. Some of the patients have been shown to have deletions in chromosome 17p13.3, and recently, LIS-1 has been proposed to be the disease-associated gene. We have now mapped the mouse homolog of LIS-1 to mouse chromosome 11B3 by using fluorescence in situ hybridization to metaphase chromosomes. The analysis of yeast artificial chromosome clones placed Lis-1 in close proximity to the microsatellite marker D11Mit65.
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