| First Author | Mertens S | Year | 1996 |
| Journal | FEBS Lett | Volume | 383 |
| Issue | 3 | Pages | 273-6 |
| PubMed ID | 8925912 | Mgi Jnum | J:32241 |
| Mgi Id | MGI:79723 | Doi | 10.1016/0014-5793(96)00255-4 |
| Citation | Mertens S, et al. (1996) SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett 383(3):273-6 |
| abstractText | Stress-activated protein kinases are MAP kinase homologues that are activated by cellular stresses, bacterial endotoxin and inflammatory cytokines. They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress-activated protein kinase-1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress-activated protein kinase-2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2). Here we report the cloning and sequencing of a new protein kinase from rat with a TGY sequence in the activation domain. This stress-activated protein kinase-3 is 60% identical to mouse stress-activated protein kinase-2 and 45% identical to HOG1 from Saccharomyces cerevisiae. Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle. |
