| First Author | Li S | Year | 1996 |
| Journal | Exp Gerontol | Volume | 31 |
| Issue | 1-2 | Pages | 195-206 |
| PubMed ID | 8706788 | Mgi Jnum | J:31632 |
| Mgi Id | MGI:79118 | Doi | 10.1016/0531-5565(95)02011-x |
| Citation | Li S, et al. (1996) Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter. Exp Gerontol 31(1-2):195-206 |
| abstractText | The expression of insulin-like growth factor I (IGF-I) is regulated by hormones, oncogenes, and other growth factors, and is markedly decreased or even absent in senescent human diploid fibroblasts. In previous articles, we have reported that the SV40 large T antigen increases the production of IGF-I and that the expression of the IGF-I gene is negatively regulated by an E2F binding site in the IGF-I promoter. We have now investigated the activity of the IGF-I promoter, in response to stimulation of cells by either PDGF or EGF. Both growth factors stimulate the activity of the IGF-I promoter, indicating that they regulate the levels of expression of IGF-I. When the E2F binding sequence in the IGF-I promoter is mutated, the IGF-I promoter is constitutively active and no longer responds to the action of growth factors. |
