| First Author | Ziółkowska B | Year | 1995 |
| Journal | Brain Res Mol Brain Res | Volume | 34 |
| Issue | 2 | Pages | 351-4 |
| PubMed ID | 8750842 | Mgi Jnum | J:31384 |
| Mgi Id | MGI:78885 | Doi | 10.1016/0169-328x(95)00209-b |
| Citation | Ziolkowska B, et al. (1995) Fos is not involved in the regulation of the proenkephalin gene by haloperidol in the mouse striatum. Brain Res Mol Brain Res 34(2):351-4 |
| abstractText | The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration. Mice were treated with haloperidol (1 mg/kg, i.p., once daily), MK-801 (1 mg/kg, i.p., twice daily), or with both those drugs for 9 days. Pretreatment with MK-801 prevented the haloperidol-produced induction of the striatal c-fos mRNA. In animals injected with haloperidol for 9 days, levels of the striatal PENK mRNA were increased by 100%. Coadministration of MK-801 did not reduce that increase. These results suggest that Fos is not necessary for activation of the PENK gene expression, produced by chronic haloperidol application, in the striatum. |
