| First Author | Darling DC | Year | 1996 |
| Journal | Gen Comp Endocrinol | Volume | 102 |
| Issue | 3 | Pages | 283-7 |
| PubMed ID | 8804558 | Mgi Jnum | J:33430 |
| Mgi Id | MGI:80910 | Doi | 10.1006/gcen.1996.0071 |
| Citation | Darling DC, et al. (1996) Nucleotide sequence and genomic structure of the chicken insulin-like growth factor-II (IGF-II) coding region. Gen Comp Endocrinol 102(3):283-7 |
| abstractText | Insulin-like growth factor II (IGF-II) is a mitogenic polypeptide with structural similarity to insulin that appears to be involved in regulating embryonic growth. While mammalian IGF-II proteins and IGF-II genes have been well characterized, little is known about avian IGF-II proteins and the genomic sequences that encode them. In this paper we report the isolation and characterization of chicken IGF-II cDNA and genomic clones. The predicted chicken prepro-IGF-II protein contains 187 residues and comprises a signal peptide (24 residues), IGF-II peptide (67 residues), and C-terminal peptide (96 residues), which share 33, 82, and 25/28% amino acid sequence identity, respectively, with their rat/human counterparts. Like the human and rat IGF-II genes, the chicken IGF-II gene has three coding exons. These are interrupted by introns at similar positions to those found in the human and rat IGF-II genes. |
