| First Author | Zeng G | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 226 |
| Issue | 2 | Pages | 319-23 |
| PubMed ID | 8806633 | Mgi Jnum | J:35258 |
| Mgi Id | MGI:82710 | Doi | 10.1006/bbrc.1996.1354 |
| Citation | Zeng G, et al. (1996) Molecular cloning of cDNA for rat brain GD3-synthase. Biochem Biophys Res Commun 226(2):319-23 |
| abstractText | The complete nucleotide sequence of the cDNA coding for rat GD3-synthase was determined for the first time using PCR and the rapid amplification of cDNA ends (RACE) procedures. The deduced amino acid sequence consists of 359 residues. The protein contains a potential transmembrane domain with a short N-terminus and such highly conserved regions as the sialylmotifs. An antisense oligonucleotide derived from the rat GD3-synthase cDNA was applied to the cultures of rat cerebellar neurons and results showed a decrease in the synthesis of ganglioside GD3, indicating that the expression of GD3-synthase was modulated by the antisense sequence. |
