| First Author | Omoe K | Year | 1996 |
| Journal | Genomics | Volume | 31 |
| Issue | 1 | Pages | 44-50 |
| PubMed ID | 8808278 | Mgi Jnum | J:30879 |
| Mgi Id | MGI:78456 | Doi | 10.1006/geno.1996.0007 |
| Citation | Omoe K, et al. (1996) Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. Genomics 31(1):44-50 |
| abstractText | Two isoforms of the human ribosomal protein S4 gene, RPS4X and RPS4Y, are located on the X and Y chromosomes. It has been postulated that haploinsufficiency of these genes may contribute to Turner syndrome. We show here that several animal species that show the Turner-like phenotype on monosomy X have no Y-linked Rps4 homolog. There may be another gene(s) that contributes to abnormal phenotypes of monosomy X. Molecular evolutionary analysis shows that the Y-linked and RPS4X-related homologs diverged prior to the radiation of placental mammals and evolved independently. Furthermore, the functional constraints against the RPS4X-related homologs are much stronger than those against the Y-linked homologs. |
