| First Author | O'Dowd BF | Year | 1996 |
| Journal | FEBS Lett | Volume | 394 |
| Issue | 3 | Pages | 325-9 |
| PubMed ID | 8830667 | Mgi Jnum | J:40197 |
| Mgi Id | MGI:87540 | Doi | 10.1016/0014-5793(96)00901-5 |
| Citation | O'Dowd BF, et al. (1996) A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. FEBS Lett 394(3):325-9 |
| abstractText | Following the cloning of the dopamine receptors we continued a search of the human genome for related genes. We searched an EST data base and discovered cDNA fragments encoding novel G protein-coupled receptor genes. The available GenBank sequence of one of these EST fragments showed that it encoded a receptor with closest similarity to the D2 dopamine and adrenergic receptors. This cDNA was used to isolate the gene (GPR19), and the encoded receptor also demonstrated similarity with the neuropeptide Y receptor. The gene was mapped to chromosome 12, in region p13.2-12.3. Northern blot analysis revealed expression of GPR19 in peripheral regions, and brain regions significantly overlapping with the D2 receptor gene expression. A sequence of the rat orthologue of GPR19 was obtained and in situ hybridization analysis demonstrated a very abundant expression in rat brain. |
