| First Author | Bhushan A | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 226 |
| Issue | 3 | Pages | 819-21 |
| PubMed ID | 8831695 | Mgi Jnum | J:35554 |
| Mgi Id | MGI:83000 | Doi | 10.1006/bbrc.1996.1434 |
| Citation | Bhushan A, et al. (1996) Expression of c-fos precedes MDR3 in vincristine and adriamycin selected multidrug resistant murine erythroleukemia cells. Biochem Biophys Res Commun 226(3):819-21 |
| abstractText | Expression of murine P-glycoprotein (P-gp), encoded by mdrl or mdri3, confers a multidrug resistance phenotype. Higher expression of c-fos and c-jun has also been demonstrated in multidrug resistant human and murine cells. We detected increased expression of c-fos early in the derivation of two series of murine erythroleukemia sublines selected for resistance to vincristine or adriamycin which eventually overexpress mdr3. We speculate that early expression of c-fos prepares cells for overexpression of other genes, such as mdr3, that contribute to the multidrug resistance phenotype. |
