| First Author | Furue M | Year | 1996 |
| Journal | Br J Dermatol | Volume | 135 |
| Issue | 2 | Pages | 194-8 |
| PubMed ID | 8881659 | Mgi Jnum | J:35309 |
| Mgi Id | MGI:82759 | Citation | Furue M, et al. (1996) Interleukin-1 but not tumour necrosis factor alpha synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells. Br J Dermatol 135(2):194-8 |
| abstractText | Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor alpha (TNF-alpha) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-alpha. In this paper, we present that IL-1, but not TNF-alpha, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC. |
