First Author | Ye Y | Year | 1996 |
Journal | EMBO J | Volume | 15 |
Issue | 20 | Pages | 5606-15 |
PubMed ID | 8896454 | Mgi Jnum | J:36516 |
Mgi Id | MGI:83942 | Citation | Ye Y, et al. (1996) Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation. EMBO J 15(20):5606-15 |
abstractText | Phosphorylation is one of the major post-translational mechanisms by which the activity of transcription factors is regulated. We have investigated the role of phosphorylation in the regulation of nucleic acid binding activity and the nuclear translocation of WT1. Two recombinant WT1 proteins containing the DNA binding domain with or without a three amino acid (KTS) insertion (WT1ZF |