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Publication : Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation.

First Author  Ye Y Year  1996
Journal  EMBO J Volume  15
Issue  20 Pages  5606-15
PubMed ID  8896454 Mgi Jnum  J:36516
Mgi Id  MGI:83942 Citation  Ye Y, et al. (1996) Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation. EMBO J 15(20):5606-15
abstractText  Phosphorylation is one of the major post-translational mechanisms by which the activity of transcription factors is regulated. We have investigated the role of phosphorylation in the regulation of nucleic acid binding activity and the nuclear translocation of WT1. Two recombinant WT1 proteins containing the DNA binding domain with or without a three amino acid (KTS) insertion (WT1ZF
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