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Publication : Gestational changes of glucose transporter gene expression in the mouse placenta and decidua.

First Author  Yamaguchi M Year  1996
Journal  J Endocrinol Invest Volume  19
Issue  8 Pages  567-9
PubMed ID  8905482 Mgi Jnum  J:36659
Mgi Id  MGI:84086 Doi  10.1007/BF03349018
Citation  Yamaguchi M, et al. (1996) Gestational changes of glucose transporter gene expression in the mouse placenta and decidua. J Endocrinol Invest 19(8):567-9
abstractText  Glucose is required for fetal development and energy metabolism. The glucose transfer from maternal circulation to fetus, in which glucose transporter (GLUT) should play an important role, is fundamental in the utero-placental-fetal system. In this study, the gestational changes of GLUT1 and GLUT3 mRNA level in the mouse placenta and decidua were analyzed by Northern blot analysis. The levels of GLUT1 mRNA in the mouse placenta and decidua increased as gestational day proceeded. Although the level of GLUT3 mRNA in the decidua slightly decreased as pregnancy proceeded, there was a switch in size of a major band of GLUT3 from 4.1 kb to 2.7 kb in the mouse placenta detected by Northern blot analysis. These findings suggest the presence of a difference in the gestational modulation of the level of GLUT1 and GLUT3 in the uteroplacental system.
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