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Publication : Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.

First Author  Kuhen KL Year  1996
Journal  Gene Volume  178
Issue  1-2 Pages  191-3
PubMed ID  8921913 Mgi Jnum  J:36425
Mgi Id  MGI:83855 Doi  10.1016/0378-1119(96)00314-9
Citation  Kuhen KL, et al. (1996) Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. Gene 178(1-2):191-3
abstractText  The pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phage and P1 phage clones from human genomic DNA and characterized by restriction mapping, Southern blot analysis, and nucleotide sequencing. The genomic nucleotide sequence, when compared to that of previously determined cDNA sequences, revealed 17 exons encoding the 551-amino-acid PKR protein. We report herein the sequence of the human PKR protein kinase deduced from genomic clones.
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