| First Author | Masat L | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 11 | Pages | 2731-5 |
| PubMed ID | 8921962 | Mgi Jnum | J:36451 |
| Mgi Id | MGI:83877 | Doi | 10.1002/eji.1830261127 |
| Citation | Masat L, et al. (1996) Loss of the beta 1 subunit of the sodium pump during lymphocyte differentiation. Eur J Immunol 26(11):2731-5 |
| abstractText | The Na,K-ATPase, or sodium pump, is responsible for maintaining cellular volume and is involved in receptor-mediated endocytosis; it is a ubiquitous transmembrane enzyme in higher eukaryotes and consists of an alpha and a beta subunit. In the mouse, two isotypes of beta with no known function have been identified: beta 1 and beta 2. We have studied the expression of beta 1 and beta 2 in lymphocytes from bone marrow, spleen, peripheral blood, and thymus. The beta 2 subunit is not expressed in any of the lymphocytes tested. Pre-B lymphocytes and the majority of mature, resting B cells in the bone marrow express the beta 1 subunit, as do all pre-T cells and mature thymocytes. In the spleen and in blood, beta 1 expression defines subsets of T and B lymphocytes. Mitogen-stimulated T and B cells lose beta 1 expression and do not express beta 2. While there is no indication that there is a change in alpha subunit isoform expression as a result of lymphocyte activation or that it is expressed in smaller amounts, there is a switch in the expression of the beta isoform. |
