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Publication : Partial cDNA sequencing of mouse dentine sialoprotein and detection of its specific expression by odontoblasts.

First Author  Ritchie HH Year  1996
Journal  Arch Oral Biol Volume  41
Issue  6 Pages  571-5
PubMed ID  8937648 Mgi Jnum  J:37481
Mgi Id  MGI:84874 Doi  10.1016/0003-9969(96)00015-5
Citation  Ritchie HH, et al. (1996) Partial cDNA sequencing of mouse dentine sialoprotein and detection of its specific expression by odontoblasts. Arch Oral Biol 41(6):571-5
abstractText  Dentine sialoprotein (DSP), a 53-kDa acidic glycoprotein, is expressed by odontoblasts and secreted into the dentine extracellular matrix. Although little is known about its biological function, it might play a part in dentinogenesis. Because DSP has only been shown to occur in rat dentine, it is important to demonstrate its existence in another species. Here, the presence of DSP gene in the mouse genome, and the cloning of a mouse DSP cDNA coding for about one-fifth of the molecule with a nucleotide sequence similar to that for rat cDNA, are reported. Using in-situ hybridization, DSP mRNA was uniquely detected in mouse odontoblasts.
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