| First Author | Chehab FF | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5296 | Pages | 88-90 |
| PubMed ID | 8974400 | Mgi Jnum | J:37525 |
| Mgi Id | MGI:84917 | Doi | 10.1126/science.275.5296.88 |
| Citation | Chehab FF, et al. (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275(5296):88-90 |
| abstractText | Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract. |
