| First Author | Rotenberg A | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 7 | Pages | 1351-61 |
| PubMed ID | 8980240 | Mgi Jnum | J:37455 |
| Mgi Id | MGI:84848 | Doi | 10.1016/s0092-8674(00)81829-2 |
| Citation | Rotenberg A, et al. (1996) Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell 87(7):1351-61 |
| abstractText | To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they lack LTP in response to stimulation at 5-10 Hz and are impaired on spatial memory tasks. In these transgenic mice, the place cells in the CA1 region have three important differences from those of wild types: they are less common, less precise, and less stable. These findings suggest that LTP in the 5-10 Hz range may be important for the maintenance of place-field stability and that this stability may be essential for the storage of spatial memory. |
