| First Author | Zhang H | Year | 1996 |
| Journal | Gene | Volume | 183 |
| Issue | 1-2 | Pages | 1-6 |
| PubMed ID | 8996079 | Mgi Jnum | J:37230 |
| Mgi Id | MGI:84632 | Doi | 10.1016/s0378-1119(96)00362-9 |
| Citation | Zhang H, et al. (1996) Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1. Gene 183(1-2):1-6 |
| abstractText | B7-1 is one of the co-stimulatory factors which plays an important role in immunity. We have cloned and functionally mapped the promoter of the murine B7-1 gene using transient transfection assays in mouse L (tk-) cells. The B7-1 basal promoter consists of three positively regulated regions. The distal region, located at -2597 to -1555, contains an assortment of putative transcription factor binding sites. The proximal upstream region, located at -130 to -110, contains a tandem repeat sequence 5'-GTGTTCTAGTGTT-3'. A downstream region is positioned at +269 to +25. We have also identified an alternatively spliced form of the murine B7-1 gene in L (tk-) cells. |
