| First Author | Fujimaki H | Year | 1996 |
| Journal | Neuroreport | Volume | 7 |
| Issue | 18 | Pages | 2951-5 |
| PubMed ID | 9116217 | Mgi Jnum | J:38072 |
| Mgi Id | MGI:85461 | Doi | 10.1097/00001756-199611250-00030 |
| Citation | Fujimaki H, et al. (1996) IFN-gamma induces expression of MHC class I molecules in adult mouse dorsal root ganglion neurones. Neuroreport 7(18):2951-5 |
| abstractText | The expression of major histocompatibility complex (MHC) class I molecules on adult mouse DRG neurones was analysed using immunofluorescence and reverse transcription-polymerase chain reaction (RT-PCR). MHC class I molecules were not expressed in untreated dorsal root ganglion (DRG) neurones. The molecules, however, were detected on the surface of neurones following IFN-gamma treatment. In addition, expression of the MHC class I beta 2-microglobulin and genes was induced in neurones following IFN-gamma treatment. Expression of Tap-1 and Lmp-2 genes, which are involved in antigen processing and presentation, was also induced by IFN-gamma treatment. These results indicated that DRG neurones are able to express MHC class I molecules following IFN-gamma treatment and suggest that DRG neurones themselves are susceptible to recognition by cytotoxic T cells. |
