| First Author | Bleul CC | Year | 1996 |
| Journal | J Exp Med | Volume | 184 |
| Issue | 3 | Pages | 1101-9 |
| PubMed ID | 9064327 | Mgi Jnum | J:35277 |
| Mgi Id | MGI:82727 | Doi | 10.1084/jem.184.3.1101 |
| Citation | Bleul CC, et al. (1996) A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [see comments]. J Exp Med 184(3):1101-9 |
| abstractText | Chemotactic factors are postulated to direct emigration of lymphocytes from the blood stream into sites of inflammation. Members of a family of chemotactic cytokines, termed chemokines, have been shown to attract lymphocytes but efficacy, i.e., the maximal percentage of attracted cells, has been low. We have identified a highly efficacious lymphocyte chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants. Purification of this chemotactic activity revealed identity to stromal cell-derived factor 1 (SDF-1). SDF-1 acts on lymphocytes and monocytes but not neutrophils in vitro and is both a highly efficacious and highly potent mononuclear cell attractant in vivo. In addition, SDF-1 induces intracellular actin polymerization in lymphocytes, a process that is thought to be a prerequisite for cell motility. Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basal extravasation of lymphocytes and monocytes rather than in inflammation. |
