| First Author | Wang GR | Year | 1996 |
| Journal | Proc Natl Sci Counc Repub China B | Volume | 20 |
| Issue | 4 | Pages | 101-9 |
| PubMed ID | 9050255 | Mgi Jnum | J:39868 |
| Mgi Id | MGI:87217 | Citation | Wang GR, et al. (1996) Immunopotentiating activity of Clostridium butyricum in mice. Proc Natl Sci Counc Repub China B 20(4):101-9 |
| abstractText | Bacterial vaccine, as generated by heat-inactivated Clostridium butyricum cells, displayed antitumor activity against sarcoma 180 in DDY mice and antimetastatic activity against B16-F10 melanoma in BDF1 mice. According to our results, the vaccine has no direct growth inhibitory effect toward the tumor cell lines tested in this study. The vaccine increased gamma-interferon production, elicited delayed type hypersensitivity reaction, and enhanced IgM antibody formation and mitogenicity. The phagocytic activity of macrophage and killing activity of NK cells from mice were enhanced in a dose-dependent manner by stimulating with the heat-inactivated vaccine. Among those responses in the mice treated with CB, elevated NK cell activity may play a prominent role in manifesting antitumor activity in the B16-F10 metastasis experiment. |
