| First Author | Brown MG | Year | 1997 |
| Journal | Immunol Rev | Volume | 155 |
| Pages | 53-65 | PubMed ID | 9059882 |
| Mgi Jnum | J:42903 | Mgi Id | MGI:1096725 |
| Doi | 10.1111/j.1600-065x.1997.tb00939.x | Citation | Brown MG, et al. (1997) The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity. Immunol Rev 155:53-65 |
| abstractText | The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level. |
