| First Author | Mashimo J | Year | 1997 |
| Journal | Cancer Lett | Volume | 113 |
| Issue | 1-2 | Pages | 213-9 |
| PubMed ID | 9065824 | Mgi Jnum | J:40415 |
| Mgi Id | MGI:87758 | Doi | 10.1016/s0304-3835(97)04700-9 |
| Citation | Mashimo J, et al. (1997) Decrease in the expression of a novel TGF beta1-inducible and ras-recision gene, TSC-36, in human cancer cells. Cancer Lett 113(1-2):213-9 |
| abstractText | TSC-36, a TGF beta1-inducible gene, encodes a polypeptide that shows significant similarity to SPARC (secreted protein rich in cysteine), and follistatin, an activin-binding protein. The expression of the TSC-36 gene was reported to be extinguished in v-ras-transformed mouse fibroblastic cells, and also was found also to be abrogated in cells transformed with v-myc. The level of expression was, however, not affected in cells transformed with v-src, v-abl, or v-raf. The TSC-36 cDNA was first isolated from mouse cells, and recently its rat and human homologues have been reported which show striking similarity with each other. In various human tumor cells, TSC-36 mRNA was almost undetectable. TSC-36 mRNA was detected in various mouse organs, but its level was the highest in the lung. TSC-36 mRNA level was the highest in the lung among mouse organs, and on in situ hybridization, the TSC-36 transcript was detected in the alveolar epithelium but not in the bronchial epithelium. These features suggest possible usage of TSC-36 as one of the markers in human tumors. |
