| First Author | Nagakubo D | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 231 |
| Issue | 2 | Pages | 509-13 |
| PubMed ID | 9070310 | Mgi Jnum | J:52842 |
| Mgi Id | MGI:1330501 | Doi | 10.1006/bbrc.1997.6132 |
| Citation | Nagakubo D, et al. (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231(2):509-13 |
| abstractText | We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative transforming activity with H-Ras, more than 3 times as strong as the activity of ras/myc combination. DJ-1 was ubiquitously expressed in various human tissues, and the expression was induced by growth stimuli. Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway. |
